Four, including a pair of youths from Toronto, have future court appearances in a Thunder Bay courtroom.
Police raided the home on May Street South at about 6:20 p.m. Thursday and picked up suspected crack cocaine, cash, and paraphernalia consistent with drug trafficking.
The estimated potential street value of drugs seized totals nearly $13,000.
A 30-year-old and 39-year-old from Thunder Bay were among the arrested.
The names of the youths are being withheld in accordance with the Youth Criminal Justice Act.